Journal of Clinical Nephrology and Therapeutics is open access and peer-reviewed scientific journal. The journal serves as a bridge between scientific explorations and findings in the clinical field. And it also implementing the development of clinically applicable medical tools and techniques.

The kidneys are formed mostly by interstitium and tubules, demonstrating the importance of a better understanding of Tubulo-interstitial Nephritis (TIN). The kidney injury caused by TIN can be acute or chronic, resulting in decreased renal function and normally accompanied by nonspecific symptoms. The Acute Tubulo-interstitial Nephritis (NTIA) is most often due to allergic drug reactions or to infections. In fact, NTIA corresponds to about 10%-15% of all cases of Acute Kidney Injury (AKI) and it is especially common in hospitalized patients. More than two-thirds of all these cases are drug-induced. The number of tubulointerstitial nephritis’ cases has increased due to the increasing number of prescribed drugs. Many drugs can induce tubulointerstitial nephritis. In our report, we describe a rare case of tubulointerstitial nephritis caused by phenytoin in a polytraumatized and hospitalized pediatric patient (previously healthy).  

The clinical spectrum of NTIA is large, patients with NTIA typically present with nonspecific symptoms of acute renal failure. The patient’s clinical picture may range from a simple asymptomatic elevation in creatinine or Blood Urea Nitrogen (BUN) or abnormal urinary sediment, to generalized hypersensitivity syndrome with the classic triad of fever, rash and eosinophilia, even culminating in oliguric renal failure. A relatively rapid decline in renal function, obtained by measuring the elevation of creatinine and BUN is common to find.

Articles that are submitted to our journal will undergo a double-blind peer review process to maintain quality and the standards set for academic journals.  The review process will do by our external reviewers which are double-blind. The comments will upload directly to the editorial tracking system. Later the editor will check the comments whether it is acceptable or not.   The overall process will take around 21 days under with the editor. After acceptance by the editor, it will be published on the Press page.  Authors can submit their manuscripts to the online submission portal.

Best Regards,
Anna Melissa
Editorial Manager
Journal of Clinical Nephrology and Therapeutics